Publications
Peer-reviewed research on inflammation — how genetic risk variants translate into mechanism in stroke. Christina Schlegl is a physician and researcher at the Biomedical Center of the LMU Munich and UKE Hamburg.
- Immunity · 2025A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosisAsare Y, Yan G, Schlegl C, et al.Some people inherit a common DNA variant near a gene called HDAC9 that raises their risk of stroke and coronary artery disease.Summary and abstract → · doi.org/10.1016/j.immuni.2025.01.003
- Nature · 2024DNA-sensing inflammasomes cause recurrent atherosclerotic strokeCao J, Roth S, Zhang S, et al.More than one in ten people who have a stroke caused by atherosclerosis have another one within days, and nobody knew why.Summary and abstract → · doi.org/10.1038/s41586-024-07803-4
- Signal Transduction and Targeted Therapy · 2022IKKβ binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responsesAsare Y, Shnipova M, Živković L, Schlegl C, et al.The textbook account of inflammasome activation is a two-step process: a first signal primes the cell, a second one triggers it.Summary and abstract → · doi.org/10.1038/s41392-022-01189-3